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KMID : 1225720110030020081
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Allergy, Asthma & Immunology Research : AAIR
2011 Volume.3 No. 2 p.81 ~ p.88
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IL-33 and Airway Inflammation
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Oboki Keisuke
Nakae Susumu
Matsumoto Kenji
Saito Hirohisa
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Abstract
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Interleukin-33 (IL-33) is the 11th member of IL-1 cytokine family which includes IL-1 and IL-18. Unlike IL-1β and IL-18, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage and may not enhance acquired immune responses through activation of inflammasome. ST2, a IL-33 receptor component, is preferentially expressed by T-helper type (Th) 2 cells, mast cells, eosinophils and basophils, compared to Th1 cells, Th17 cells and neutrophils. Thus, IL-33 profoundly enhances allergic inflammation through increased expression of proallergic cytokines and chemokines. Indeed, IL-33 and its receptor genes are recognized as the most susceptible genes for asthma by several recent genomewide association studies. It has also recently been shown that IL-33 plays a crucial role in innate eosinophilic airway inflammation rather than acquired immune responses such as IgE production. As such, IL-33 provides a unique therapeutic way for asthma, i.e., ameliorating innate airway inflammation.
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KEYWORD
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IL-33, ST2, host defense, allergy, autoimmunity, chronic disease, mast cell, basophil, eosinophil
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